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The use of mutagenesis in invertebrates to generate phenotypic variants has a long and productive history.
Each of these variants has a unique histomorphologic appearance, which raises a number of different differential diagnostic considerations, with the attendant clinically relevant management decision.
It isn't clear that every one of those variants has a different biological activity, of course.
In the no selection model (simulation A), there is no selective pressure because each of the variants has a 50% chance of winning the competition event.
However, CENP-A, like other histone variants, has a distinct expression pattern.
Therefore, research in the area of rare variants has a high potential to discover unknown associations of genomic regions with complex phenotypes.
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All of the variants has an integrated type / tuner/ in-dash 6 CD changer / MP3 / WMA.
Trace analysis indicates that the self-accommodated variants have a coherent twinning plane of {1¯2¯5} relative to the martensitic phase.
Of those, 1,020 RMA variants have a corresponding ClinVar entry, with 19 in-coding sequence variants having "pathogenic" (15) or "likely pathogenic" (4) clinical significance, including the previously described variant in BBS2.
Surprisingly, when compared to wild-type PTPRS, 4/7 tested native variants had a measurable deleterious effect on PTPRS function as measured by ERK activation (Fig. 7).
Quantification of the abundance of each charge state reveals that in each case the S32 variants have a significantly greater abundance of unfolded protein (Fig. 1F).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com