The importance of the loop D475-G481 is further backed by the phenotype of the H479Q variant generated in this study.
Of the 29 HCCS variants generated, 17 exhibited defects in the release of matured cytochrome c, with substitutions in domain IV comprising the majority of these nonfunctional mutants.
With antibody pI variants generated using site-directed mutagenesis in the Fab region, Igawa et al. demonstrated that variants with pI values of 1 2 units lower than the wild type displayed longer half-lives and reduced clearance following both subcutaneous and intravenous administration (Igawa et al., 2010b).
Since E-1 carries or is linked to one or more causal disease allele responsible for renal disease, when its benefits are lost outside of Africa, neutral variants generated by recombination would rise in frequency replacing the costly haplotype, as may be the case in Asian populations.
Almost all CPEBs exist in multiple variants generated by alternative mRNA splicing (Theis et al., 2003; Wang and Cooper, 2009).
However, despite the phenomenon of AS is known for more than two decades, the list of biological roles for splice variants generated from a single gene in plant stress is not completed and poorly understood.
Using the word variants, generated by static and dynamic models, in the lexicon of the SHENAVA Persian continuous speech recognizer, relative word error rate reductions as high as 8.1%andd 11.6% are obtained, respectively.
Because of this adaptive process, epitopes presented by common HLA variants are generated in low amounts, whereas epitopes presented by rare HLA variants are made in abundance.
The weak [PSI+] phenotypes of some strains (e.g. A4) could be caused by weakened propagation of the same prion variant or by the formation of a different prion variant To test the possibility that different, structurally distinct, prion variants are generated in the presence of different Hsp70 orthologs, we focused on A1 and A4 that have normal and weak prion phenotypes, respectively (Figure 5A).
