Sentence examples for variants function from inspiring English sources

Our biochemical, gene expression, and phylogenetic data suggest that the H2A.Z-1 and H2A.Z-2 variants function similarly yet they may have acquired a degree of functional independence.

As a result, how most of these individual variants function is currently unknown.

Approaches that provide a mechanistic understanding of how genetic variants function to alter disease susceptibility and why they were substrates of natural selection would complement other approaches to human-genome analysis.

These variants function independently of the systemic disease and increase substantially the risk of DLE with an effect even higher than in SLE.

Together our biochemical and computational findings support the hypothesis that the de novo variants function as dominant negative mutations.

It is also possible that rare variants function as compound heterozygotes, with a different rare variant present on each allele.

Susceptibility/resistance to Chagas disease involves multiple genetic variants functioning jointly, each with small or moderate effects.

In contrast, all variants functioned similar to wild-type (WT), being able to substantially rescue vps35-mutant phenotypes including one assay of endosome-to-TGN recycling.

The following section describes our tests for the effects of sample size, the proportion of risk variants, and variants functioning in opposite directions in seven different simulated pedigree settings.

(3) The proposed adaptive intensity transfer function is a spatially variant mapping function associated with the local statistical characteristics of the image.

We have discussed ongoing community efforts to address these challenges, including clinical-grade sample collection, digitalized phenotyping, acquisition of high-quality sequencing data, rigorous generation of variant calls, comprehensive functional annotation of variants, and biological validation of variant function.