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Prevalence of germline variants for these seven monomorphic loci was not significantly different between sporadic CRC and HNPCC patients (Table S2).
This gene family is possibly conserved by natural selection in mammalian species or, with a different view, could mean a relative relaxation of selective pressure on copy number variants for these genes.
Fine scans of these regions will definitely identify more susceptibility genes and causal variants for these common diseases.
Presence of genetic variants for these transporters could contribute to the dFdCTP variability that we and others have observed.
This is at least in part because of the absence of the genome sequences and the lack of comprehensive catalogs of genomic variants for these strains.
Further GWAS and causative mutations studies in the autosomes might be done in the future in order to identify more informative variants for these traits.
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We chose these seven variants for the pragmatic reason of cost and effort.
The consequences, if any, of these evolutionary variants for the functional regulation of the AZFc genes remain to be assessed.
To synthesize and identify the custom-made LacI variants for sensing these four new inducers, the team designed a novel workflow incorporating a combinatorial synthesis strategy that relies on computational protein design and the Wyss Institute's custom DNA synthesis resources to build a variant library of potential new biosensor designs comprising hundreds of thousands of mutated LacI proteins.
It is polygenic as it contains several different MHC class I and MHC class II genes and it is the most polymorphic human gene known with hundreds of variants for some of these genes [50].
We found the two variants for each of these exons.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com