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However, LBP and most of its variants fail to achieve such discrimination ability. .
Likewise, in AAT deficiency, misfolded AAT variants fail to exit the ER and are targeted for ERAD.
Our experiments also indicate that conventional LBP and its variants fail to capture these age-based differences.
"It is now clear that common risk variants fail to explain the vast majority of genetic heritability for any human disease," they wrote in an essay, arguing that many of the hundreds of GWAS findings to date "stem from factors other than a true association with disease risk".
In this situation, many true variants fail to be identified because they are present in haplotypes that differ from the genome used as index, and thus reads generated from these regions are not aligned and are lost.
Since Shroom3 R1838A and R1838C variants fail to bind Rock or cause apical constriction, we wanted to test if they are also incapable of activating Myosin II by assaying the phosphorylation status of RLC in polarized MDCK cells expressing these Shroom3 variants.
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All these variants failed to produce an efficient result.
Forty of the proposed 62 behavior variants failed to meet the necessary criteria for traditions [3] for four reasons presented in bands A D of Table S2.
However, most QMC variants failed to return trees on most inputs.
All TED Cys/Ala variants failed to pull down fibrinogen from plasma.
Nonetheless, analysis of 10 of these variants failed to detect seven of them in a set of controls.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com