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Examples from other gene variants exist, for example the GNB3 825C>T polymorphism [39], where the largest association is seen among carriers of heterozygous genotypes.
A number of splice variants exist for IFI16, IFIX and Ifi203, detailed elsewhere [ 22, 63].
If multiple transcript variants exist for a given gene, all variants containing an alternative ORF are listed.
Matching metabolites by name is not an ideal solution, as many, possibly ambiguous, synonyms and spelling variants exist for the same metabolite [ 36].
For example, several genetic variants exist for genes encoding glutathione S-transferases (GSTs), which play major roles in the metabolism of glucosinolates and bioavailability of isothiocyanates that are present in cruciferous vegetables (broccoli) [ 296, 297].
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In addition to schizophrenia and bipolar disorder, evidence for a contribution of COMT variants exists for panic disorder [ 10, 11], attention deficit hyperactivity disorder [ 12], obsessive compulsive disorder [ 13], phobic anxiety [ 14] and anorexia nervosa [ 15].
We found that nine of the twenty two GA metabolism pathway genes were responsive to yeast extract and Ag+-treatment in S. miltiorrhiza hairy roots and tissue-specifically expressed splice variants existed for SmKO, SmGA20ox3, SmGA2ox3 and SmGA2ox11.
Several variants exist to accommodate for different problem types.
Since pathogenic germline mutations always exist in a heterozygous state within germline DNA and homozygous germline variants only exist for non-clinically important variants such as polymorphisms, HRM is thus ideal for minimizing the burden of sequencing.
Isolated "hot spots" for single nucleotide variants exist, but there is little or no information regarding the overall contribution of such regions to eukaryotic SNP formation.
A number of spectrally distinct FAP variants exist and have been used successfully for live cell confocal microscopy and flow cytometry studies.
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