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We also found that Nore1/Rassf5-deficient mice, which are deficient for both Nore1A and Nore1B/Rapl splice variants, exhibited normal numbers of peripheral blood lymphocytes, even though the numbers of T cells in lymph node and spleen were reduced (Figure S8A).
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The father of the index patient, an L212P carrier lacking this Cx40 variant, exhibited normal sinus rhythm [34].
Hdac6 transgenic mice exhibited normal fertility and sex ratio.
In comparison, untreated cells had normal nuclei and exhibited normal morphology.
Control Otx2flox/CreERT2 animals exhibited normal retinal histology.
The mRGC-ablated mice exhibited normal outer retinal function.
These mice also exhibited normal electroretinogram (ERG) (Figure 3B).
DRG neurons exhibited normal neurite outgrowth in both cultures.
As expected, Cby+/+ lungs exhibited normal PV relationships.
They moved all four extremities and exhibited normal locomotor activity.
Heterozygous females exhibited normal lymphoid development and were indistinguishable from normal control females (data not shown).
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