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In the Hemminki's study, subjects ⩾50 years of age carrying the XPD variants exhibited lower DNA repair.
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On the other hand, the P509S PD variant exhibited lower k cat of 0.017 min−1 for basal ATP hydrolysis (P < 0.05; Fig. 1A).
The microorganism harboring the variant enzyme exhibited lower accumulation 3-HPA, less inactivation of the two enzymes that produce 3-HP from glycerol, higher cell growth, and higher 3-HP production than that with the wild-type enzyme.
In a Danish study of >7,000 healthy participants, the finding of an association with risk of type 2 diabetes was not replicated for the rs1071592 variant; rs4917/rs4918 exhibited lower insulin resistance and fasting insulin but were not associated with risk of type 2 diabetes (10).
All of the metastatic variants exhibited a lower level of NOS II expression than the parental Panc02 cell line did.
Saturation mutagenesis at Ile211 and combination mutagenesis Ile211/L156M/H268L were performed subsequently to further improve OPH activity; however, all the other variants exhibited extremely lower OPH activities than AbOPHI211A (Additional file 1: Figure S5).
At the same time OA tenocytes exhibited lower expression of soluble Fas, which is produced as an alternatively spliced variant of Fas and has been shown to exert antiapoptotic effects [ 18].
JFH1/5AC-Q24K/L28M/R30Q/A92K exhibited lower replication and virus production efficiencies.
The pattern VEP exhibited lower amplitudes and prolonged peak times.
The injured paw exhibited lower reaction latency.
Cellular experiments show that the Arg325 ZnT8 variant exhibits lower apparent Zn2+ transport activity than the Trp325 ZNicolsonolson et al., 2009).
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