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After correction for multiple testing based on false discovery rate and considering the number of analyzed polymorphisms, significant associations were shown for four variants, even though none of these associations survived a genome-wide correction (P < 5 ∗ 10− 8).
The BFM also discriminates LND from variants, even though it is not a criterion for separating these groups.
Of note, such a sequencing depth was sufficiently high to discover most (99.7%) of the variants even though the exome capture was biased against variant carrying alleles.
It is important to note that Oryza has the greatest number of intron-exon structure variants even though rice has fewer CAD genes than Populus and apparently less overall chromosomal duplications.
However, we have previously shown that turbidity measurements give an estimate of aggregation, but, due to the different morphologies of the aggregates, the values can substantially differ between different TTR variants, even though the total aggregated protein is the same.
The estimate using all the genetic variants is more precise than the estimate using only a subset of variants, even though the additional variants are not associated with calcium at nominally significant levels.
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As a consequence, female speakers were less likely to adopt this new variant, even though they welcomed others (e.g., [D]).
However, young Chiang speakers nowadays did not consistently use this variant even though it had been a robust realization once, and it is likely to die out soon in the near future, which is consistent with Ang's 洪惟仁 (2003, 2012) predictions.
reported a different drugs sensitivity of various EML4-ALK variants 31, even though this phenomenon has not been observed in clinical setting.
In contrast to the effect of homopolymer sequences on discordant SNP calls, the logistic regression analysis results showed that homopolymer sequences in the SNP loci effected Ion Proton variant calls more strongly than they affected HiSeq variant calls, even though the overall effects were not significant (Table 5 and Figure 5).
Nevertheless, SomaticSniper gave low sensitivity in low-allelic-fraction variant calling, even though it achieves the highest sensitivity for the 100% "pure tumor" sample.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com