Sentence examples for variants each with from inspiring English sources

Today 3D parallel illumination exists in several complementary variants, each with a different degree of simplicity, light uniformity, temporal precision and axial resolution.

The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses.

The hereditary component of migraine, i.e. the proportion of individual differences explained by genetic variation in migraine, is estimated to be between 38 and 53% and is likely to arise from the combined effect of many common risk variants each with small effect sizes, thus characterizing migraine as a common complex, polygenic disease [2 4].

In the CDRV hypothesis, phenotypic variation is attributable to multiple variants, each with a low frequency and a small to moderate marginal effect.

The success of this approach relies on the common disease-common variant (CDCV) hypothesis, which presumes that phenotypic variation of common diseases is explained by several common variants, each with a relatively small effect [1], [2], [3].

The latter proposes that complex phenotypes result from multiple rare variants, each with relatively high penetrance and large effect sizes (Schork et al. 2009).

Wild-type PhilD and the PhilD* variant, each with an upstream KanR cassette, were integrated into their native locus, leading to strains UA1888 and UA1889, respectively (Table 1).

One explanation may be that blood pressure is determined by the combination of a large number of gene variants, each contributing with a small effect, and thus the conducted studies have been underpowered.

GWAS in a very diverse maize collection identified seven SNP variants each associated with between 1% and 3% of trait variation.

In fact, >95 variants each were associated with 6 of these low quality DNA samples, of which >75% of the sample-specific variants were detected with a mutation frequency of <10%.

Because of the multi-factorial nature of complex traits, each individual genetic variant generally has only a modest effect, and the interaction of genetic variants with each other or with environmental factors can potentially be quite important in determining the observed phenotype.