Such methods are typically limited to characterization of relatively few variants due to the difficulties in generating large rational libraries.
With respect to CH several studies have explored potential relationships with clock gene variants due to the striking circadian and circannual periodicity of attacks.
Assuming a longer operation of the unit under lower loads would exclude the application of the EBPT and MC variants due to a substantial decrease in the unit efficiency with load.
Further data curation, comprehensive data coverage and improvements are planned for subsequent Metrabase releases, as well as inclusion of additional biochemical annotations (especially with respect to sequence variants due to their importance in phenotypic variation, e.g. in drug metabolism).
Single-species and two-species cultures were used to determine whether different asexual lineages have different capacities for producing variants due to epistatic constraints, and whether their survival is determined by local inter-lineage competition with different species.
As a result, exotic product variants are often sold unprofitably, since dissimilar products are, of course, more expensive than standard variants due to higher adjustment costs for their development.
It has to be stressed however that DUD-E was found to be not ideal to benchmark the virtual screening performance of global shape similarity algorithms such as USR and its variants due to the large variations in molecular size of the active ligands.
The re-emergence of major variants due to subsequent drug challenge (e.g. antiretroviral therapy) [40], [41] was not modeled.
Ordinary variant-by-variant methods that are suited for analyses of common variants have a limited capacity to detect rare variants due to their extremely low frequency.
Any HIV sample contains a population of related but genetically diverse variants due to the high misincorporation rate of the HIV-1 RT [8], [27], [28].
Sequence alignments produced by ClustalX v.1.83 [70] were examined to detect false allelic variants due to PCR errors by comparing sequences within and among individuals.
