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Functional analyses indicated that some of these variants display altered regulatory function consistent with dominant inheritance.
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Nevertheless, when functionally tested GluA3 variants displayed altered channel function either in homomeric combination or in heteromers with normal GluA2.
In support of this, primary mouse fetal liver-derived megakaryocytes transfected with ACTN1 variants displayed altered pro-platelet formation and size [ 37].
Furthermore, aging brains display altered levels of neural irregularity.
Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.
'Miracle-Wheat' and 'Compositum-Barley' display altered, branched inflorescence architecture.
Neutrophils display altered membrane expression and cell function following transmigration.
They also display altered metabolism with increased mitochondrial respiration.
Next, we tested whether Salm3−/− synapses display altered synaptic plasticity.
Non-labouring SCS fetal membranes display altered morphology and altered apoptotic biochemical characteristics in preparation for labour, while the laboured SOR displays unique MMP characteristics.
Additionally, we demonstrated that the overexpression of the most frequent TPI variant, Glu104Asp, which displays altered dimerization features, results in diminished endogenous TPI levels in mammalian cells.
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