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Assembly of the 5S rRNA gene confirmed three variants (data not shown); downstream of the 5S rRNA gene, all three variants differ from Methanoculleus marisnigri JR1, indicating a different genomic context for the rrn cluster.
These variants differ from one another by the presence of either C or T nucleotide at codons 112 and 158.
Most of these variants differ from each other at the second (X) and/or fourth (Z) amino acid position in the cyclic heptapeptide.
However, it has not been addressed whether these variants differ from the standard genetic code as far as mutation and translation loads are concerned.
CenH3 variants differ from the other H3 variants by a long extension of the N-terminal tail, which are not conserved among eukaryotes [ 5, 6].
Variants differ from canonical histones in their protein-protein interactions, localization in chromatin, number and types of PTMs, nucleosome stability, and tissue-specific expression profiles [ 5].
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Comparison of the frequency of variants differed from EP in both groups of patients (P=0.01) with an odds ratio (OR) of 5.14 (CI 95% [1.07 26.56]).
FMS patients and family members without rare variants differed from control subjects with regard to both TH1 (IFNγ) and TH2 (IL-5 and IL-13) cytokine levels (Figure S2).
Each of the variants differed from the original MCF-7 line in ploidy, modal cell volume, and signaling pathway usage.
The in vitro and in vivo phenotypes of cells expressing glycosylation site variants differed from cells expressing fully-glycosylated ICAM-2 or no ICAM-2.
Moreover, each of these rare variants differed from all other sequences by a single non-synonymous (amino acid altering) substitution at an otherwise invariant site.
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