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The in silico predictions thus suggest mechanisms by which the TLR4 upstream region sequence variants could affect TLR4 protein expression.
It is suggested that one or more of the four missense variants could affect the quality (or quantity) of the gene products and cause mild functional impairment in the receptor's responsiveness to IL-12 [25].
Presumably, the underlying genetic variants could affect pigment content or myoglobin content, which in turn could affect meat color.
Since PAH converts phenylalanine to tyrosine which is a precursor of dopamine and other catecholamines, functional PAH variants could affect synthesis of catecholamines.
Given the presence of novel genetic variants affecting the precursor of miRNA, but not the mature miRNA itself, we tested whether such variants could affect their secondary structure and thereby block processing into the functional mature miRNA.
Both cis-regulatory and trans-regulatory coding variation via MSR variants could affect the degree of pQ β-sheet interdigitation between the pQ tracts of TFs binding to adjacent sites in cis.
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We next investigated whether overexpression of the hPolλ W438 variant could affect mutation frequency in vivo.
How does the reduced fidelity of the W438 variant could affect NHEJ and chromosome instability?
How this variant could affect P-gp expression is still unknown [ 6].
Therefore, we constructed the plasmids containing the rs9383935 G or A allele to determine whether this variant could affect gene expression.
In addition, with the evidence obtained from the bioinformatic tools, the structure-modeling analysis strongly suggests that this variant could affect the protein function.
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