For most complex traits we have a poor understanding of the positions, phenotypic effects, and population frequencies of the underlying genetic variants contributing to their variation.
Inability to replicate many results has led to increasing scepticism about the value of simple association study designs for detection of genetic variants contributing to common complex traits.
These include new phenotyping methods for genetic studies and new study designs such as case control and whole-genome association studies to identify common variants contributing to the trait.
These regions may represent genetic variants contributing to development of islet autoimmunity in T1D.
GWA studies have already proved successful and reported novel, unanticipated genetic variants contributing to disease risk.
These regions may represent genetic variants contributing to islet autoimmunity or disease onset and could be used to assess risk of developing T1D.
The identification of genetic variants contributing to common forms of obesity has been challenging using traditional strategies for selection of candidate genes.
Genome-wide SNP association (GWA) studies have provided an important opportunity to discover genes with sequence variants contributing to bone density variations, and hence, osteoporosis.
