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Of note, 2.7% of children previously assessed with a clinical grade comparative genomic hybridization microarray were found to have pathogenic copy number variants, compared with 6.1% of those with no previous clinical grade microarray.
Additional file 4: Effect on coverage and ability to detect variants compared with DNA input.
An individual exome has more than 20,000 variants compared with the reference genome.
GFP fluorescence was brighter for all CMVarI variants compared with the respective CMVarII variants.
For the 29 mtDNA sequences, we observed 662 mtDNA variants compared with the rCRS (Supplementary Table).
In TH-positive neurons, total numbers of LC3 puncta were higher for all αSyn variants compared with EGFP.
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Thus the RR for the combination of the heterozygous and the variant form compared with wild type were computed.
But, Hakonarson says, the work is exciting for two reasons: 65% of kids in the study had that variant, compared with just under 60% in the control group--a difference that, across a population, is significant, he says.
Mean CL, the volume of serum antibody cleared per unit of time, was approximately 1.2-fold lower for the YTE variant compared with WT in mice (WT, CL = 0.01063 ± 0.0029 mL/min/kg; YTE, CL = 0.00897 ± 0.00224 mL/min/kg; P < 0.05; Table 1, Fig. 1E), indicating a significant decrease in the clearance of the YTE variant.
The scientists found a "significant" difference between the women whose water broke early and the women whose babies were born at term: Among the women with PPRM, 11.5 percent of fetuses had the key genetic variant, compared with 4.5 percent in the non-PPRM group.
The selective advantage of an escape variant compared with the wild type was estimated from longitudinal viral sequence data showing the replacement of the wild type by the escape variant [30].
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