Sentence examples for variants characterized in from inspiring English sources

Failure to identify new loci suggests that the NMRI population carries mostly the same allelic variants characterized in complex traits analyses using classical inbred mouse strains.

Variants characterized in this study were produced in pLM1-CD6(17) and were expressed in BL21-Gold cells for 18 h at 24 °C and purified as previously described.

Furthermore, the comparison with the AOMT1 and FAOMT characterized previously [ 11, 12] showed that AOMT2 variants characterized in this study tend to produce a lower proportion of Mv 3-glc, with a preferential catalysis of the 3' O-methylation.

In fact, H2B sequence variation is conserved among higher eukaryotes [ 24], and some of the variants characterized in other organisms may have counterparts with similar functions in human cells.

The six germline pol ι variants characterized in this study can be classified into three types according to the changes of relative polymerase efficiencies opposite G and the lesions in the presence of the added metal (Mg2+ or Mn2+) compared to wild-type (Tables 2– 7).

In this work protein variants characterized by mutations in functional domains of SBE enzyme have been identified and analyzed by bioinformatic tools able to predict the effect of the amino acid substitution on protein structure and functionality.

All additional variants characterized and sequenced in each round are shown in Supplementary file 1. DOI: http://dx.doi.org/10.7554/eLife.06492.003 10.7554/eLiFigure92.004 Figure 1 figure supplement 1. Correlation between activities measured in cell lysate and using purified enzyme for all variants selected over the evolution ( Supplementary file 2 ).

All additional variants characterized and sequenced in each round are shown in Supplementary file 1. DOI: http://dx.doi.org/10.7554/eLife.06492.010 Next, we set out to answer the question how the two enzymes exhibiting identical phosphotriesterase activity, wt- and neoPTE, are connected on the adaptive landscape.

Indeed, severe cardiac fibrosis was observed in lethal cardiac variants characterized by cardiomyocyte deposits in the absence of endothelial deposits [ 16].

Methodologies to improve existing adeno-associated virus (AAV) vectors for gene therapy include either rational approaches or directed evolution to derive capsid variants characterized by superior transduction efficiencies in targeted tissues.

The identified OCT1 variants were characterized in vitro regarding their cellular localization and their ability to transport 10 known OCT1 substrates.