Sentence examples for variants causing human from inspiring English sources

The two Zaire (EBOV) variants causing human outbreaks in 2014 in West Africa countries (mainly Guinea Konacry, Sierra Leone and Liberia) and in the Democratic Republic of Congo have been demonstrated, using phylogenetic analysis, to be distinct from each other and from variants known from previous EVD outbreaks.

First, pharmacogenomics has identified more than 70 genes for which specific variants cause humans to metabolize drugs ineffectively (too fast or too slow).

Virulent variant obtained from hamster ALA should be similar to the amoebae causing human infection.

Many human variants causing behavioural disorders are not gene deletions but changes in levels of expression or activity of a gene product; consequently, large-scale mouse ENU mutagenesis has the advantage over the study of null mutants in that it generates a range of point mutations that frequently mirror the subtlety and heterogeneity of human genetic lesions.

Allelic variants causing loss-of-function put human individuals at risk to develop obesity14.

In recent years, exome sequencing (i.e. the sequencing of the full complement of protein-coding exons in the genome) has therefore become a favoured approach in identifying sequence variants causing rare as well as common human diseases [ 9- 11].

Additionally, altered Trak1 protein expression is associated with gastric and colorectal cancers (Zhang et al., 2009; An et al., 2011) and recently, whole exome sequencing has identified pathogenic variants in Trak1 that cause human fatal encephalopathy (Barel et al., 2017).

Motivation: High-throughput-sequencing (HTS) technologies are the method of choice for screening the human genome for rare sequence variants causing susceptibility to complex diseases.

Salmonella, a genus of more than 2500 serological variants (serovars), includes many organisms that can cause human disease.

DNA sequencing identified several A. phagocytophilum variants, including a predominance of strains known to cause human disease.

In contrast, the big brown bat RABV variant and the Myotis RABV variant caused one human case each, even if these bats frequently occupy house attics and crevices in men-made constructions.