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Splice variants can increase the proteome diversity and cellular function.
Similarly, variants that strengthen natural splice sites are also likely to be neutral, though these variants can increase retention of exons that are otherwise frequently alternatively spliced.
(48) The number of cholesterol variants can increase by an order of magnitude by including cholesterol/24-alkyl sterol derivatives to esters, glycosides, and sulfates and those metabolites that retain the perhydro-1,2-cyclopentanophenanthrene skeleton.
There may also be interaction between genetic mutations to modulate melanoma risk further; for example, some MC1R gene variants can increase the penetrance of CDKN2A mutations, thus increasing risk further [56,57].
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When ectopically expressed, contrarily to the tumor suppressive KAI1, this variant can increase in vitro invasiveness and in vivo tumorigenicity.
Lehmann and colleagues use this approach to analytically derive the conditions under which an altruistic variant can increase and show that the conditions are less restrictive under vertical inheritance than horizontal transmission because emigrants leave the group and therefore, there is less competition among descendants in the vertical case.
The main impact of uncoordinated plug-in electric vehicle (PEV) charging is adding new time-variant loads that can increase the strains on the generation units, transmission and distribution systems that may result in unacceptable voltage drops and poor power quality.
Our hypothesis is that ADH1B*47His can enhance the activity of ADH enzyme and the derived allele of the promoter variant of ADH1B can increase the quantity of the enzyme in the body; thus the protection against some related diseases will be stronger and the ADH1B haplotype will be selected.
Some rare variants can greatly increase the risk of disease and should be easier to detect than others.
Furthermore, it confirms that weighting the scores from different variants can further increase power.
Purifying (negative) selection against deleterious variants can also increase LD, as the deleterious haplotypes are swept from the population [ 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com