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In this proof-of-concept study, we tested the hypothesis that combined analysis of multiple genetic variants can improve prediction.
An important question therefore is whether addition of genetic variants can improve prediction accuracy for fracture beyond that which can be determined by clinical risk factors alone.
[ 35] (Abstract) "The degree to which currently known genetic variants can improve the prediction of CHD risk beyond conventional risk factors in this disorder was investigated".
To investigate whether genetic variants can improve the EBV IgA antibodies test method for NPC diagnosis, we extended previously reported GWAS associations with NPC to Han Chinese from Southern China the highest NPC incidence region.
One limitation to the broader application of such testing is that the magnitude of increased risk conferred by each variant is relatively small (although there is evidence that testing for these 40 variants can improve reclassification of diabetes risk for individuals under the age of 50 [ 11]).
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As populations expand, the number of mutations increases, boosting the chances for a beneficial genetic variant that can improve survival and sweep through a population (in the same way that a large population of insects develops a gene for resistance to a pesticide faster than a small population).
Parasites having a high dynamic range of on- and off- probabilities within their variant gene families can improve their survival in naïve as well as re-infected hosts.
The results of this study show for the first time that incorporating data on the immunohistochemical characteristics of tumours arising in carriers of these variants can sometimes improve the prediction of pathogenicity.
Mismatch rates in the ORPs offer locus-specific information on error rates and thus can improve variant call accuracy.
This study shows that five GWAS identified variants were also consistently validated in this Chinese population and combining these genetic variants with other risk factors can improve the risk predictive ability of breast cancer.
The preclinical program described here demonstrates that the incorporation of gain-of-function factor IX variants at amino acid 338 can improve circulating factor IX activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com