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This example suggests that multiple and population-specific risk variants can exist at one gene.
These structural variants can exist as differences in gene copy number, but can also be caused by larger insertion and deletion events [ 32].
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Since different chromatin variants (epialleles) can exist in the same sequence background (i.e., on the same sequence allele), they can produce a dimension of functional variation at the population level that cannot be captured by an analysis based on DNA sequence alone (J ohannes et al. 2008).
Seeman [10] emphasized that even though some of his alienation variants can be related, no theoretical structure exists.
Of note, there may be misclassification of cellular variant as tip variant because cellular lesions can exist within the tuft in tip variants and intracapillary expansile foam cells can be observed in both variants depending on location; either at the polar domain in tip variants or at any other location in the cellular variants.
In the context of parallel MCMC, two basic algorithms exist: running multiple chains and parallelism within a single chain, yet some variants can be useful as well.
Three variants can be seen enroute.
Design issue III - execution of variants: Variants can be executed either sequentially or in parallel.
Some variants can be prioritized for functional follow-up.
Each of these two variants can further exist as an "a" or "b" form, which differ by a 9-nt extension at the end of exon 4. The "a" and "b" variants are not distinguishable in microarray profiling experiments [ 9].
In conclusion, the HLA-G5 soluble splice variant of HLA-G can exist as a dimer identically to HLA-G1 at the cell surface.
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