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The absence of deletions spanning the NAA10 gene in controls according to the Database of Genomic Variants can either point to the assumption that heterozygous loss-of-function in females is pathogenic or more likely that this relatively gene-dense region shows a low activity for genomic rearrangements.
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The rearranged (intermediate) chromosome bearing the variant nucleotide can either persist in the population and, therefore, be found, as in the case of Hb Frankfurt [ 5] or can subsequently be lost.
Design issue III - execution of variants: Variants can be executed either sequentially or in parallel.
Sucrase-isomaltase variants can occur on either sucrase or isomaltase subunits, resulting in varied effects on sucrase-isomaltase enzyme activity [16].
Variants can be executed either sequentially or in parallel and variant outputs can be adjudicated by adopting different voting and acceptance algorithms (Daniels et al. [1997]; Laprie et al. [1990]).
The rate at which variants appear between the paralogs can be estimated as the genome average per nucleotide mutation rate multiplied by twice the length of the repeats (as variants can arise in either repeat).
Nevertheless, CD synthesis may become even more environmental friendly if CGTase variants can be obtained, either via screening or protein engineering, that effectively convert native starch granules into specific CDs.
Genetic variants can affect RNA expression through either cis or trans mechanisms or both.
The effects of ALS-causing variants on the free energy landscape of SOD1 shown in Figure 7 suggest a potential mechanism through which the ALS variants can oligomerize and exert toxicity by either a significant destabilization of the dimer, e.g., A4V, significant destabilization of the monomer, e.g., G93A, or a combination of both events, e.g., L38V and L106V.
You either have the gene variant or you don't, so you can either taste PTC or you can't; and, by the same token, you can either taste the bitterness in sprouts, or you can't.
These annotated variants can then further be interpreted by filtering based on either quality, functional, or genetic criteria.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com