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These changes extend further than the petrol engine as bi-fuel LPG variants benefit from an eight percent reduction in fuel economy when run on LPG.
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In addition, one of the two variants benefits from an improved sensitivity.
While it was not possible to perform metabolite and kinetic analysis at this stage, further work aiming to explore EFB scaffold variants could benefit from such data.
If these results are confirmed, patients with <10% X4 variants might benefit from maraviroc therapy.
Since patients with somatic BRCA pathogenic variants may benefit from treatment with poly ADP ribose polymerase inhibitors, it is important to be able to test for somatic changes in routinely available tumour samples.
Patients carrying certain obesity-prone NPGPx genetic variant may benefit from antioxidant therapy.
The immediate benefit of this study for the clinical management of patients with ESS is that the detection of the fusion protein greatly aids in diagnosing high-grade variants that may benefit from adjuvant chemoradiotherapy.
Thus, individuals with the variant allele may benefit from a protective effect against cancerogenesis.
However, at present this strategy should not be used as a substitute for comprehensive germline BRCA analysis in patients at high risk of having a pathogenic BRCA1/2 variant, but could be used to identify individuals with somatic only BRCA1/2 variants who may potentially benefit from PARP inhibition therapy.
For the c.1905+1G>A variant, we agree with previous reports suggesting that the severity of side effects will be reduced by a dose reduction of 50 60% before the start of therapy (Deenen et al, 2011; Yang et al, 2011; van Kuilenburg et al, 2012), while patients carrying the other variant DPYD genotypes may benefit from a lesser dose reduction of 25%.
With the advent of treatment-focused BRCA testing and the potential of patients with somatic as well as germline BRCA pathogenic or likely pathogenic variants in ovarian tumours to benefit from PARP inhibitor therapy [ 16], there is an increasing clinical need for routine BRCA screening of FFPE tumour DNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com