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The H3mm6 18 genes are predicted to be replication-independent histone variants, because they have polyadenylation signal sequences and are located outside the histone clusters.
"You want the low-frequency, high-impact variants because they are the ones that are going to have more impact on the biology," said Dr. Jeffrey Gulcher, chief scientist at NextCODE Health, a deCODE spinoff that sells software and services for genomic studies.
However, caution should be taken when studying these non-coding variants, because they have no direct functional meaning in terms of affecting gene expression, and the relationship between their conservation and phenotype may not be well established.
This present paper reports the population analysis for the disulfide-containing apo-forms of these variants because they provide a common reference state for both wild-type-like and metal-binding variants and because apo-SOD1 is thought to be involved in the formation of aggregates [16], [32], [33].
We could not perform neutralization assays on position-272 variants because they did not grow in culture.
We have specifically focussed on non-synonymous variants because they will alter the amino acid sequence of gene products, which may result in different phenotypes [ 33].
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Let's go.' " Still, Mr. Foster said, he is pleased the company is dropping "Smile" and its longer variant because they "had nothing to do with the brand" and "could have been for Colgate, United Airlines, Disneyland or Hertz".
Genomic (i.e., chromosomal) rearrangements longer than 50 nucleotides are often considered structural variants (SVs), because they have a direct effect on the structure and behavior of the chromosome and cause variation in gene dosage.
The ligament changes more likely reflect normal variants, also because they were not related to trauma factors and were equally frequent in non-injured controls, as reported elsewhere [ 38].
For example, BWASW, SHRiMP2, SMALT, SSAHA2 and TMAP, might perform particularly well for sequencing focused on rare variant discovery because they show a robust discrimination of variations.
Cryptic variants are special because they have a higher proportion of tinkering variants and fewer lethal ones.
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