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Genome-wide association studies recently identified variants at several loci associated with body mass index [ 20].
Recent GWAS have reported that variants at several sites within the IRF4 gene may be implicated in the risk of cancer.
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Copy number variants (CNVs) at several loci are now robustly associated with schizophrenia (1– 7).
Large and rare copy number variants (CNVs) at several loci have been shown to increase risk for schizophrenia.
High-throughput technologies, such as microarray, mass spectrometry and especially the newly developed NGS, have provided tremendous potential for profiling variant molecules at several levels with unprecedented resolution, depth and speed.
Natural variation in thermomorphogenesis caused by ELF3 variants could be mediated at several levels.
The two clades differ at several variants including those affecting TAP2 splicing.
We have determined the structure of HbpA from the soil bacterium Pseudomonas azelaica HBP1 with bound 2-hydroxybiphenyl, as well as several variants, at a resolution of 2.3 2.5 Å to investigate structure function correlations of the enzyme.
Herein, several variants at amino acid residue 117 were also identified, including known variants G117N and G117R that confer resistance.
We expected multinomial-shaped distributions with one peak at very low frequency values corresponding to artifactual variants and several peaks at medium-high frequency values corresponding to true variants.
They play an important role in gene regulation by covalent modification at several sites and histone variants replacement.
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