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Inheritance of genetic variants at one or more loci results in reduced DNA repair capacity.
In this case, the distinction between variants at one locus vs multiple loci is irrelevant, as is the distinction between diploidy and haploidy.
In this case, the distinction between variants at one locus versus multiple loci is irrelevant, as is the distinction between diploidy and haploidy.
Association studies compare two groups of samples (cases and controls) for statistical differences in the frequency of variants at one or more sites of the genome.
The cost of genotyping, for instance, meaning the identification of specific genetic variants at one or more loci in an individual, has dropped by more than 100-fold, making the initiative's genome association component more affordable.
An excess of sequence variants at one extreme relative to the other that is not due to chance or to population stratification constitutes evidence for genetic association and implies the presence of functionally significant sequence variants.
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It samples one genetic variant at one location, and compares it to all variants in the data set at the same location across the data set, producing a working estimate of population structure.
Moreover, real-time PCR methods are only able to detect a single VKORC1 variant at one time.
The term epistasis was coined to describe a genetic 'masking' effect viewed as a multi-locus extension of the dominance phenomenon, where a variant at one locus prevents the variant at another locus from manifesting its effect [ 2].
The term epistasis was coined to describe a genetic "masking" effect, viewed as a multi-locus extension of the dominance phenomenon, where a variant at one locus prevents the variant at another locus from manifesting its effect [ 5].
Variant groups are disqualified as classes if it can be shown that a tumor of a certain type may progress from one variant group to another variant group over time (e.g. slow-growing variant at one stage in development and fast-growing variant at another stage).
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