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Developmental plasticity may operate through two mechanisms: (1) a threshold response to environmental stimuli whereby a developmental switch produces alternative forms (i.e., a developmental polyphenism), or (2) somatic or developmental selection, whereby large numbers of variants are produced and some variants are selectively preserved while others are eliminated [ 55].
Consequently, H3 variants are selectively targeted by post-translational modifications, possibly as a result of deviations within the recognition motifs, which allow binding of effector proteins.
These variants are selectively neutral in DM25 medium, but Ara- and Ara+ genotypes can be distinguished by their red and white colonies, respectively, on tetrazolium-arabinose (TA) indicator agar.
Moreover, Nck binding to certain splice variants of the "a disintegrin and metalloprotease" ADAM15 points to a role of Nck in malignancy since these variants are selectively increased in breast cancer cells [ 33].
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Specific variants were selectively targeted by PTM.
In addition, coreceptor use of the different clusters was predicted genotypically and compared with the U87.CD4 cell culture outcome to determine if certain coreceptor-using virus variants were selectively lost.
We further document that expression of Gi-coupled but not Gs/Gq-coupled EP3 splice variants is selectively up regulated following serum deprivation, indicating that cAMP-reducing EP3 receptor variants are regulated by the proliferative vs. quiescent status of the CRC cell.
Although there is strong evidence that NANOGP8 is a retrogene expressed in cancer cells, there is no evidence in our data or in previous publications to contradict the assumption that variants in NANOGP8 are selectively neutral.
Two-component adsorption at pH 7.5, where the deamidated variants are bound selectively also showed markedly different profiles for the two matrices.
Furthermore, if variants capable of vector transmission are selectively disadvantageous, then their frequency in the population might be extremely low.
In the first one (selective grouping), two sets are selectively formed: one in which each variant has a greater frequency in cases than in controls, and the other in which each variant has a greater frequency in controls.
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