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Together, our data demonstrate that hinge domain null AR splicing variants are resistant to SPOP-mediated degradation.
Furthermore, these variants are resistant to the RNAi, potentially by stoichiometrically overwhelming this cellular mechanism.
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The variants were resistant to inhibition by nerve agent model compounds of soman (i.e., SPGD3N), sarin (i.e., SPGB3N), and cyclosarin (i.e., SPGF3N).
In contrast to WT IGFBP-2, the PR variant was resistant to proteolysis by proteases present in T84, SW480 and MCF-7 CM.
Figure 1D and Table 2 shows that while the DLKPA variant is resistant to docetaxel, both parent cell line DLKP and its drug-resistant variant DLKPA are equally sensitive to EL102.
The antibiotic susceptibilityshowed the KP producing novel KPC variant was resistant to most of the antibiotics, such as carbapenem (imipenem, ertapenem and meropenem), aztreonam, cephalosporin (cefazolin, cefotaxime and ceftazidime), but susceptible to amikacin and colistin.
Rilpivirine, a second-generation NNRTI, will be used in first-line regimen therapy, but the prevalence of minority variants that are resistant to rilpivirine is unknown.
An additional important implication is that tannic acid could be used for treatment for engineered anthrax variants that are resistant to available vaccines.
While Rifa-GE is as potent as GE or Rif, it also effectively inhibits RNAP variants that are resistant to either.
Research efforts have been directed toward identifying hBChE variants that are resistant to organophosphorus compounds that could provide a basis for new catalytic bioscavenger therapies.
hBChE variants that are resistant to OP or nerve agent model compounds have been developed on the basis of the protein structure of hBChE.
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