Sentence examples for variants are predicted from inspiring English sources
Several of the novel mutations identified in this study that both lead to amino acid substitutions and are present in the compound heterozygous state, with other previously known variants, are predicted to affect protein function of podocin using two SNP prediction algorithms; Sorting Intolerant From Tolerant (SIFT) and Polymorphism Phenotyping (PolyPhen).
No splice variants are predicted by these ESTs.
Most of the variants are predicted to alter protein folding while several other map to functional surface regions.
The familial variants are predicted to have pathogenic consequences on the protein whereas the control variant p.Ser75Phe is predicted to be benign.
All LRR variants are predicted to be destabilizing by at least three methods, meaning that all variants could have a negative structural change (Table S1).
Most variants are predicted above 95% accuracy.
The selection of martensitic variants was predicted well by the minimum strain work criterion.
For in silico analysis of nonsynonymous variants, R150S and rs35062132(R376G) were predicted to be damaging by SIFT with a score of 0.002 and 0.021, respectively, whereas the other two missense variants were predicted to be tolerated.
Previously, research WGS of matched tumor and normal samples was performed at the Washington University Genome Sequencing Center (WUGSC), and somatic variants were predicted by two independent bioinformatics pipelines (St . Judeand WUGSC) and validated by custom capture sequencing21.
Three loss-of-function variants were predicted by LOFTEE.
Three LoF variants were predicted by LOFTEE (see Additional file 1: Table S3).
