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Alternatively UL37 spliced variants are exceedingly low abundances relative to the UL37x1 unspliced transcript, some ~100 fold less and below detection by RT-PCR and gel detection, so the alternatively UL37 spliced variants cannot be detected by either S1 or Northern blot analysis [ 17, 18].
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With the exception of three common variants in VAPB, all others are exceedingly rare in the population (Table 4) and heterozygous in the IPDGC dataset.
However this study also highlights the challenges of identifying genes involved in common complex disease, namely, that numerous genes, mostly of small effect sizes, are likely to contribute to periodontitis, and that discovery of individual variants may be exceedingly difficult.
Here, high fitness variants do not grow to higher titers in the absence of competition, yet are exceedingly better at competing for cellular resources.
They are exceedingly fra‐.
And microgenerators are exceedingly clean.
The challenges are exceedingly complex.
Such interactions are exceedingly rare.
Fatal elevator accidents are exceedingly rare.
Such requests are exceedingly rare.
Insanity acquittals are exceedingly rare.
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