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Variants are then tested empirically and further variants are created based upon their performance.
In the process of AS additional variants are created among the mature mRNA transcripts through modification and rearrangement of exons (e.g. [14], [15]).
Notably, these data also confirm that full-length TALEN protein is present in LPs despite the fact that the truncated variants are created by internal cleavage.
Finally, it is also possible that the size distribution for inversions differs from that of CNVs based on the mechanisms by which the variants are created.
Under the birth-and-death evolution model, new variants are created by gene duplication and can remain as functional genes in the genome or become pseudogenes.
This is so because the viral polymerases responsible for replicating the genome have a high error rate and therefore, many genomic variants are created at a high generation rate [ 1, 2].
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Four variants were created.
A family of stabilized variants was created including a consensus-driven triple variant, A275P/N186D/V622I.
To diminish the risk of generating a human anti-mouse antibody response in patients, chimeric variants were created.
These three variants were created from practical reasons they enable convenient description of the shape of rasters for calculation.
Based on sequence alignment and structural modeling, a library of enzyme variants was created by a semi-rational evolution strategy in position Thr238 and Pro242.
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