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In order to determine which variants are capable of inducing T cell responses, the DQ2-Glia-α1, DQ2-Glia-α2, DQ2-Glia-α3, and DQ8-Glia-α1 variants were synthesized as 15- or 16-mer peptides and tested for their capacity to bind to HLA-DQ2 and induce in vitro proliferation of HLA DQ2- or DQ8-restricted T cell clones.
A preliminary bioinformatic analysis showed that both DNA variants are capable of forming G-quadruplexes, however, with varied stability.
However, these novel FP receptor mRNA splicing variants are capable of heterodimerization with wild-type FP receptors.
Both variants are capable of inhibiting action potential firing (Jomphe et al., 2006; Jang et al., 2011; Dragicevic et al., 2014).
Both mono-culture (Patabendige et al., this issue) and co-culture (Skinner et al., 2009) of the PBEC model variants are capable of giving monolayers of TEER >400 Ω cm.
Together, these results indicate that both variants are capable of growing in B-holo-Lf as an iron source, but virulent amoebae resist the variations in the iron concentration of the environment and apparently use B-holo-Lf more efficiently than nonvirulent amoebae.
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These RGD-containing AcAP5 variants were capable of interacting with platelet receptor αIIbβ3 as shown in computational analysis.
Based on the fact that multiple rare MEFV variants were capable of causing FMF if present on both chromosomes, we decided to test the transmission of rare variants from parents to offspring collectively.
Interestingly, both N-WASP variants were capable of driving actin tail formation, although reduced efficiency of N-WASPΔA was reflected e.g. by increased expression levels required for inducing prominent actin tails (not shown).
Although both promoter variants were capable of conferring localized GUS expression in the phloem, the CsSUS1p-2 alsole also generated a significant level of expression in non-target tissues.
All of the PAL-E or tuftsin binding site variants were capable of abolishing VEGF-NRP1 binding, but unfortunately, also eliminated SEMA3-NRP1 binding.
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