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This study attempted to move beyond single genetic polymorphisms to a more comprehensive investigation that identifies genomic variants and patterns and performed early relapse analysis.
In the current study, we have attempted to move beyond single gene polymorphisms to a more comprehensive pathway evaluation to identify genomic variants and patterns that may help predict clinical response and overall survival to platinum-based chemotherapy, thus ultimately leading to a more tailored approach to chemotherapy.
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Some of the limited specificity can be partially addressed by a thorough knowledge and experience of normal variants and common patterns to avoid misinterpretation.
Other variants and development patterns are possible in niches (Bruckner et al. 1996; Kemp et al.1998; Schot and Geels 2007).
However, interpretation of FDG PET/CT studies may be difficult due to the inherently complex anatomical landmarks, certain physiological variants and unusual patterns of high FDG uptake in the head and neck.
However, the interpretation of FDG-PET/CT studies in the head and neck may be quite challenging due to the inherently complex anatomy, physiological variants and unusual patterns of FDG uptake after radiation therapy and surgery [1, 2, 3, 4, 6, 7, 8, 9].
The present study was performed to characterize HBV variants and genetic patterns of lamivudine resistant HBV strains in a patient co-infected with HIV-1 at different periods of an antiretroviral treatment with and without lamivudine.
Transgenic lines were generated for the single- and triple-tagged variants and resulting expression patterns investigated.
Polymorphisms within the sampled CRt population implied the existence of several strain variants, and showed mutational patterns that might be a sign of selection on synonymous sites.
MLST provides a useful tool to study both the local and global distribution of isolates such as those with the AHU- phenotype, making it possible to track particular variants and examine transmission patterns.
The relationship between sequence variants and DNA methylation patterns in different sets of individuals may also provide insight into complex traits in which a particular environmental exposure associates with a trait only if incurred at a particular developmental window.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com