Sentence examples for variants and modifications from inspiring English sources

Monoclonal antibody and Fc fusion protein drugs are complex heterogeneous mixtures of numerous different protein variants and modifications.

Human subcutaneous fat tissue acquired from elective abdominal surgery could be a readily obtainable source for the analysis of histone variants and modifications related to obesity, type 2 diabetes and the metabolic syndrome.

The variants and modifications of the histone proteins are related to chromatin structure [ 3- 6].

These studies have shown that specific histone variants and modifications are found to be associated with different regions of the genome to define active euchromatin and silent heterochromatin.

In addition to TF binding, the ChIP assay can also be used to profile the distribution of the chromatin modification components, histone variants and modifications [ 10].

Changes in nucleosome position and occupancy, histone variants and modifications, and chromatin remodeling are also critical elements of dynamic transcriptional regulation, but poorly understood at enhancers.

Alterations in gene expression and coding function, splice variants, and posttranslational modifications influence fibrin structure and functionality.

Low effect size common SNP variants, rare and private variants, DNA copy number variants and epigenetic modifications are together believed to account for most of the inherited risk.

Correlation studies of histone variants and their modifications in fat cells with disease characteristics could therefore identify disease-specific histone marks.

Nuclear architecture can be altered by a number of distinct pathways including ATP-dependent nucleosome remodelling, linker histone proteins, histone variants and covalent modifications to the histones and DNA [10].

Common single nucleotide polymorphisms (SNPs) that tag risk haplotypes across the genome currently account for a non-trivial portion of the germ-line genetic risk and we will likely continue to identify the remaining missing heritability in the form of rare variants, copy number variants and epigenetic modifications.