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An association between shedding of variants and lower RSV F serological response was observed but it was not possible to establish a definitive clinical significance due to the small number of subjects in this study.
Sequencing of CTC DNA identified known HCC mutations but more low-frequency variants and lower coverage depth than FFPE or PBMC.
These authors reported an association between these variants and lower area under the time-concentration curve SN-38G to SN-38 ratio.
By comparing the derived allele frequency spectra, we found that both gene duplications and HT genes showed an excess of low frequency variants and lower mean frequency relative to synonymous SNPs across the genome, and nonsynonymous SNPs in parts of the genome.
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The aim of the study was to investigate if the association between COBLL1 rs7607980 genetic variant and lower insulin resistance was present early in life.
In mothers who smoked beyond the first trimester of pregnancy, there was an association between the variant and lower birth weight, but not in mothers who smoked only in the first trimester, although this observation requires further careful evaluation.
As BPS reduces process variants, standardization implies less variation and lower costs.
In contrast, in Symbiodinium sp. the peridinin-chlorphyll a-protein gene had many different amino acid variants and a lower copy number [16].
The diagnosis of skin neoplasias becomes inaccurate, in some cases, due to a variety of factors that affect the test accuracy, such as a huge spectrum of tumors and their variants and the lower differentiation [ 8].
In support of this hypothesis are our observations of a greater breast cancer risk in women with two inherited 5972T variants and a lower frequency of positive family history among 5972C/T heterozygotes.
Although pools biases the SNP discovery process towards common variants and have lower power than individual sequencing [ 21], our simulation indicates that we should expect to detect almost half (47%) of all SNPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com