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We evaluated the performance of both ECFP variants and could not observe a significant difference.
A total of 2,926 individuals had a genotype call for all variants and could be included in the analyses.
The population in hospital acute care was at higher risk for NoV outbreaks cause by novel variants and could be an important target for molecular surveillance for new strains.
These sequence gaps likely contain many repeated sequences and structural variants and could also be fragile.
Presence of novel activation loop motifs are new variants and could offer new type of gene regulation in plants.
This suggests an infection with two different variants, and could be related to a high infection pressure in the environment.
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However, we were unable to design a Taqman assay for this variant and could not genotype it directly.
As such the association we observe with R61H may not necessarily mean it is the underlying causative variant, and could be tagging one of these two variants or another, yet to be uncovered mutation event.
Amplification of the proto-oncogene c-myc, a well-known negative prognostic marker for MBL, has been associated to LC/A variant and could contribute to its aggressive behaviour [ 24, 25].
These data suggest that the association between mtDNA variants and longevity could be highly geographically or population dependent, as could be seen from other genetic studies on longevity [17].
Such innovations could provide interventions that are effective for neuronopathic variants and, potentially, could be more cost effective than other treatments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com