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These variants also displayed an increased sedimentation capacity when grown in static cultures.
Some of the potassium channel variants also displayed functional impairment [ 54].
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These AAV serotypes or variants also display different transduction profiles in vitro.
Some other cancer variants also display increased PTPRZ expression [ 38].
However, trisomic hESC variants also display characteristics similar to cancer stem cells; they exhibit a reduced doubling time and teratomas arising from trisomic hESC injection contain a higher percentage of undifferentiated cells similar to teratocarcinomas formed following embryonal carcinoma cell injection [ 3].
At pH 7.0, the Y29F variant also displays a predominant low-spin species.
Using site-directed mutagenesis of native SGSH, we identified an improved secretion variant that also displayed enhanced uptake properties that were mannose-6-phosphate receptor independent.
Finally, in SLC2A5 two DIND outlier variants in CEU also displayed a high FST ranks (table 2), suggesting that a selective sweep has occurred in CEU.
Shortest paths connecting the functional hit and variant genes are also displayed for additional context.
Interestingly, these data show that the UPR is activated by the most destabilized amyloidogenic variants, which also display a distinct rough-eye phenotype (Fig. 6 D, E).
The variants also exhibit better coulombic efficiencies.
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