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Other variants affecting other regions of the protein could also cause changes in the protein activity.
Moreover, it has been described that variants affecting other regions of the miRNA structure can also adversely effect its functionality [ 9].
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The objective of this study was to replicate the association between FTO SNPs and "body fatness" measures in our sampled population and to examine whether FTO variants affected other obesity related anthropometric measures.
Apart from the D3 domain variants, deregulated splicing mechanism affecting other domains are also associated with tumorigenesis.
This is likely due to the extensive use of AI, disseminating long-range haplotypes from popular sires in the population even in the absence of direct selection, to strong genetic drift in populations with small effective size or to the selection for other variants across the genome (affecting other selected traits).
New experimental methods such as Hi C are now providing data on chromatin three-dimensional organization [ 9], and cases of variants affecting the expression other than the closest gene have been found, for example [ 10].
Although explanation at a functional level is a matter for future studies and finding is not significant in the GWAS established genome-wide level of significance, we propose that the European variant behind LP, and perhaps other variants affecting the regulatory region of LCT, contributes to human obesity.
In the analyses of breast cancer in younger women, possible interactions between CYP17 genotype and other gene variants affecting the tissue-specific synthesis and metabolism of steroid hormones do not appear to have been investigated.
Other mechanism types, such as variants affecting expression of genes remote in the DNA sequence, will contribute in other loci.
Other Missense single nucleotide variants affecting BRCA1 and BRCA2 were identified.
On the other hand, studies analyzing variants affecting the vitamin K dependent coagulation system in preterm infant cohorts are scarce [ 7].
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