Sentence examples for variants affecting different from inspiring English sources
This GWAS revealed associations of markers with multiple traits, which may indicate pleiotropy of one single tagged causal variant, LD between distinct causal variants affecting different traits, or genetic correlation among traits.
Thrombo inCode® (TiC) enables diagnosis of hereditary thrombophilia (by analysing genetic variants affecting different points of the blood coagulation cascade function, promoting the development of VTE) and is also a clinical genetic function for assessing the risk of VTE.
Given that the cancer is a result of interplay of various types of genetic changes, understanding of the role of somatic mutations in tumorigenesis is a complex problem in which different combinations of somatic variants affect different network of genes and associated pathways.
In the case of modularity, it means that among gene variants that affect different numbers of traits, those gene variants are selected which affect lower numbers of traits, as well as certain combinations of traits.
All the six COL-99 variants are subject to alternative splicing affecting different exons.
The variants found affect different miRNAs known to be involved in 57 diseases.
Sequence variants affecting phenotypes between different individuals were believed to be mostly due to small differences, such as single nucleotide polymorphisms (SNPs) [ 1- 4].
They did not find any identical mutations to the index tumour, however, three tumours (two lobular, one ductal) harboured non-synonymous variants/deletions affecting the ERBB2 kinase domain and two tumours (both lobular) contained different truncating variants affecting the HAUS3 gene.
We identify two different fold-preserving variants affecting RB1N that are defective for the interaction with XRCC6.
Moreover, common and uncommon variants affecting the same or similar phenotypes at different levels may coexist on the same gene and confer independent risks [23], [24].
Comparison of the different variant groups ((A) variants affecting cysteine residues and T50M, (C) the low-penetrance variants R92Q and P46L and (B) all other SVs) showed remarkably few differences which reached significance.
