The best variants are shortlisted and reorganized for another round of library creation which is repeated a number of times to possibly get the best variants, a process which follows the rule of natural evolution but is performed at a pace that gives the result of evolution in a short time [ 49].
After phagocytosis by host alveolar macrophages, C. burnetii delays phagosome lysosome fusion, presumably to change from small-cell variants to large-cell variants, a process that allows this bacterium to thrive in the acidic environment of the phagolysosome (Zamboni et al., 2003; Parker et al., 2006).
Moreover, one of the most popular means for implementing functional process flexibility is "flexibility by design", a strategy that requires incorporating alternative process variants in a process design at build time and selecting the most appropriate variant at runtime (Schonenberg et al. 2008).
In chronic untreated infection, 70-75% of all subjects recognize the subtype B consensus SL9 sequence [55], [56], [58] and >90% recognize one or more of the common variants [61], suggesting that the development of responses against this epitope, and epitope variants, is a process that continues beyond the first years of infection, as only 6/11 recognized this epitope after the first year.
After spending millions on development, Obama has unilaterally decided to shift resources toward more complex future missile variants -- a process notorious for being obscenely over budget and off schedule -- while rejecting the Congress' more sensible approach to fiscal responsibility and a more robust national defense.
However, this strategy requires extensive cloning to achieve the desired sensitivity for minor variants detection, a process, that is, costly and time consuming.
The latter requires extensive cloning to achieve high sensitivity for minor variants detection, a process that is costly and time-consuming.
If, according to a distinct process variant profile, a process context is served by the respective process variant prior to BPS and the master process after BPS, its periodic demand relatively decreases by (f_{c}) to (D_{t,c}^{text{std}} = left( {1 - f_{c} } right)w_{c} D_{t}).
To narrow down the number of variants, a filtering process is hereafter necessary.
To help bias marker selection in favor of such variants, we devised a process that prioritizes annotated SNPs for genotyping studies based on their location within Multi-species Conserved Sequences (MCSs) and used this process to select SNPs in a region of linkage to a complex disease.
To identify pathogenic variants, a stepwise filtering process was used that firstly removed non-coding, synonymous and common variants (minor allele frequency, MAF >0.005 in the 1000 genome project database or our in-house database of >800 exomes).
