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Consequently many genes under the QTL will contain or be close to a variant with that SDP.
A paired two-tailed t test was used to compare the phagocytic capabilities of each variant with that of wild-type CR3.
A χ test was used to compare the allele frequency of each variant with that expected for a population in Hardy-Weinberg equilibrium.
Here, we compared the expression profiles of HeLa cells transfected with one or the other BRCA1 variant with that of HeLa cells transfected with BRCA1 wild-type.
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Our recent study compared the distribution of these truncated YFP-SERT variants with that of Texas Red conjugated wheat germ agglutinin (WGA), a lectin marker for the plasma membrane [15].
To test whether these amino acid substitutions could similarly improve tTA, we introduced the V9I, F67S, F86Y and G138D mutations and compared the activity of these variants with that of the wild-type tTA (tTA2S [ 6]).
It will also be important to compare the genome sequence of the thermotolerant variants with that of wild type to determine the genetic changes involved in the acquisition of thermotolerance.
Chemical and thermal denaturation analysis monitored by activity, fluorescence, circular dichroism, and differential scanning calorimetry showed that certain variants with exchanges that weaken dimer dimer interactions exhibited complex denaturation profiles with active dimeric and/or inactive monomeric intermediates appearing at low denaturant concentrations.
Therefore, variants associated with specific populations will be both routinely linked to other variants associated with that same haplogroup and will also be present at a significant frequency within the overall population of mtDNA sequences.
Table 2 lists the specific activities of the LC variants, along with that of whole BoNT/A, at a fixed concentration of substrate.
The ROC values were computed for each syndrome separately, using only the test-set variants associated with that syndrome.
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Justyna Jupowicz-Kozak
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