Each variant is therefore supported by at least two sequences.
The substrate specificity range of the V41Y variant is therefore narrower than that observed for wild-type cADO with a preference toward short-chain aldehydes.
Which receptor binding avidity phenotype can be considered the 'deleterious' variant is therefore subject to which individual the virus finds itself in, as well as the overall degree of herd immunity in the host population (Yuan and Koelle, 2013).
This variant is therefore expected to perturb signaling downstream of PKD1, a kinase with roles in the development and metastatic progression of several cancers including prostate, breast, gastrointestinal, pancreatic, and skin cancers (Sundram et al., 2011).
The causative SNPs or SNP, or other genetic variant, is therefore most likely to be in this section of the gene, which includes promoter variants, intronic, codon changing, and 3'untranslated SNPs, any of which could be, or could contribute with others, to the functional effect of the haplotype.
The 8 cm–1 shift in ν(CO) for the H242A variant is therefore not inconsistent with the Cu(His)2S(Met CO coordination proposed for the low-pH CO complex of the H-center in the WT protein, but the His-Met donor power, ligand conformation, or the site polarity must be different in the H single-site variant.
The initial set of 59 variants was therefore designed in several stages as we obtained information about these parameters.
The functional impact of these variants was therefore further assessed by their potential to alter disorder propensity, a known disease-mechanism, using PONDR, as was previously undertaken (20, 21) (Fig. 4).
