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However, the observed β-galactosidase activity resulting from the interaction between wild-type TPI and the TPI2ndATG variant was lower compared to the β-galactosidase activity measured in yeast co-expressing wild-type TPI proteins (Fig. 5A, middle panel).
Adenoviral expression of the P279S variant in SR-BI-deficient mice led to a reduction of the cholesterol ester uptake capacity of hepatocytes in these mice when compared to wild-type SR-BI, and the cholesterol efflux from monocyte macrophages obtained from carriers of the P279S variant was lower, as compared to noncarriers (Vergeer et al, 2011).
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Note that the relative power of imputation appears lower under trait association model (A), where the maximum MAF of any causal variant is lower than under model (B).
The level of holocytochrome c for the C15A variant is lower than wild-type according to the intensity of the absorption spectra normalised for cell mass.
Moreover, the optimal pH values for oxidation of VA (pH 1.6) and RB5 (pH 2.5) by the S168W variant (not by the S168W-environment variant) are lower than those found for P. ostreatus VP1 (pH 3.0), an interesting improvement considering that enzymatic ligninolysis is favored by acidic pH.
But Ca quantity, accumulated in aboveground plants biomass in the experimental variants was lower than in the control.
The Ti/Tv ratio of the rare variants was lower, as expected, at 2.91.
The validation rate of the 18 putative diagnostic variants was lower than that of the other two classes, with only 31717%) proving diagnostic within the validation panel.
As LD between SNPs and causal variants are lower in African than in European populations, it is more difficult to achieve significant threshold for association analysis [11].
The proportion of 74.9% converted variants is lower than in a similar study in chicken, where 82.0% of the variants could be converted into successful variants [ 28].
However, the coverage of low frequency coding variants are lower in non-European populations given the discovery of coding variants are primarily from European ancestry individuals.
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