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With decrease in Km, catalytic efficiency of Pro247-Ser variant was increased by 12 fold.
The melting temperature (Tm) of this variant was increased by 5 °C with simultaneous improved long-term stability.
Moreover, intrinsic fluorescence intensity of Glu138Pro variant was increased and its ANS fluorescence intensity was decreased, whereas no considerable changes were observed in the far-UV CD spectra.
The specific activity of the purified epitope-tagged GUS variant was increased by up to ∼500-fold by the addition of an equimolar concentration of a monoclonal antibody.
The risk of CAD associated with 9p21 variant was increased in the presence of poor glycemic control in type 2 diabetes [ 8].
In order to keep the same value for the rate of mutation per gene, the genomic mutation rate of the variant was increased by a factor G/ L, in comparison with genomes with single-copy genes only.
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However, in these cells, much more PKCalpha/PKMalpha was ERalpha-co-immunoprecipitated at over-confluence, a condition in which the shorter, approximately 46 kDa ERalpha variant is increased.
The number of the resolved CYP21A2 haplotype variants was increased to 61 by bioinformatic haplotype reconstruction.
As the mean number of variants was increased from 96 to 377.7, the unadjusted power for the single-marker test increased to 0.88, 0.814, 0.918 and 1 for RD, OR, Cohen's h and joint analysis methods, respectively.
Therefore the potential to detect more causal variants is increased.
This paper describes, for the first time, the expression pattern of the LBD-truncated AR splice variants AR-V1, AR-V7 [14] and AR-V567es [16] in PC bone metastases in patients and, furthermore, that levels of those variants are increased in CRPC bone metastases and that expression of the AR-V567es and/or very high levels of the AR-V7 is found in individuals with particularly poor prognosis.
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