However, the substrate specificity of the three variants is altered significantly.
We found the protein folding, stability and bioactivity of CP variants were altered significantly and the CP sites of active variants were mainly located in the flexible loops.
In this study, we set out to determine if the expression levels of PDE4 isoform variants are altered during the AS to AI transition and if this has consequences for cellular proliferation.
The rates of conversion among monomeric αS, prefibrillar oligomers, and mature fibrils in the A30P and A53T disease variants are altered from wild-type behavior in a manner that may allow a dangerous accumulation of early oligomeric species (30, 31).
Another possibility is that because this variant, similar to other identified 3'UTR variants, is altered by "context", in this case estrogen, which will be altered by body habitus as well as the societal acceptance of hormone replacement therapy, it would make it more likely to be missed in mixed populations such as those used in GWAS studies.
In its original definition by Bateson, epistasis described a phenomenon in which a discrete phenotype derived from a genetic variant in one locus was altered by a genetic variant at another locus [2].
We demonstrated that the balance between Zfhep1 and Zfhep2, the splice variants of ZEB1, was altered in EAE-susceptible rats when compared to protected rats.
In that work, the affinity of variant tRNAVal2Bs for EF-Tu was altered by mutation of a portion of the aa-tRNA stem that binds directly to EF-Tu.
To probe whether the relative expression of the D2-autoreceptor splice variants in SN DA neurons was altered after cocaine injection, we quantified D2 short and long variants, and calculated D2l/s ratios in SN DA neurons from juvenile mice with and without cocaine treatment.
Bioinformatic tools predicted that all four variants occurred in sites likely to bind transcription factors and that binding was altered by the variant allele.
