Sentence examples for variant turnover from inspiring English sources

The epidemic variant turnover from clade 2A to 2B-1 during 2005 2007 was due to the effect of the intra-subtype reassortment and drift mutations (Table 2 and 3).

A genome wide steady state measurement of histone variant turnover rates was made in cultured insect cells independent of transgene induction lag times using the methionine analog azidohomoalanine (Aha).

In quiescent human lymphocytes that were stimulated to re-enter the cell cycle, different histone H3 variants were observed to exchange with each other [ 29, 44] Because our steady-state measurements were performed on actively dividing and asynchronous HeLa cells, it is likely that this difference would not be observed generally for H3 variant turnover.

Because high-performance liquid chromatography (HPLC) fractionation is able to resolve H3.1, H3.2 and H3.3, we can examine the H3 variant specific turnover of peptides with particular modifications [ 43].

Do the exon variants undergo turnover within the array and, if so, how rapidly?

Although the wild-type enzyme showed higher affinity for the ginsenosides than the W361F variant enzyme, the turnover number and catalytic efficiency of the W361F variant enzyme for ginsenoside Rd were 11- and 3.7-fold higher, respectively, than those of the wild-type enzyme.

However, this approach fails if a splice variant has similar turnover but distinct functions, or the spliced exon does not carry a polymorphism.

The results give some support for an influence of the HTR2C variant on norepinephrine turnover in men, but do not favour a major differential influence of DRD4 gene activities on monoamine metabolite concentrations in lumbar CSF.

In this study, we made quantitative measurements of the DNA glycosylase activity of Pa-AGOG wild type and some engineered variants under single turnover conditions.

The molecular mechanisms underpinning this genetic merit within a population are typically undefined but are likely to arise from polygenic changes in gene transcription mediated by genetic variation in promoters, transcriptional regulatory elements such as enhancers and insulators, and mRNA splicing sites as well as variants affecting mRNA turnover.

As a main conclusion, Trp-377 appears responsible for the high-turnover catalytic site, since its substitution (W377S variant) completely prevented high-turnover oxidation of RB19 and DMP (and decreased over 40-fold the catalytic efficiency of high-turnover ABTS oxidation).