Sentence examples for variant transcript is from inspiring English sources

As this variant transcript is represented in all the clinical breast cancer subgroups, and mainly confined to the tumor, ACOX2-i9 could be a possible independent target for therapy.

Total RNA was collected, and the presence of the variant transcript was verified by cDNA sequencing.

Northern blot analysis of Atp6v0a4 transcript abundance of total RNA isolated from P21 kidneys from Atp6v0a4−/− mice suggested that the variant transcript was subjected to nonsense-mediated RNA decay (Fig 1C).

The variant transcript was first characterized by Sanger sequencing of a subset of the patient samples (n = 26), confirming that it includes a ~70 bp intronic sequence from intron 9 (data not shown).

Kaplan-Meier survival analysis for relapse free survival was performed on the patient cohort and ACOX2-i9 was a statistically significant predictor of outcome in this dataset, where presence of the variant transcript was associated with better outcome (p = 0.04) (Fig.  5a).

We also importantly noted that several of the examined CRPC bone metastases (AR-V high cases) expressed LBD-truncated AR proteins at levels comparable to the ARfl protein levels, even though the corresponding AR variant transcripts were found at relatively much lower levels than the ARfl mRNA.

These variant transcripts are differentially regulated during testis development.

PDE4A super-short form splice variant transcripts were detectable in EST libraries of S. scrofa, B. taurus, R. norvegicus, M. musculus, C. jacchus, and H. sapiens.

ADAM-12L (membrane-bound long variant) transcripts were overexpressed in tumours when compared to controls, while no expression of short form of ADAM-12 (ADAM-12S) (secreted short variant) was detected in the lung tissues examined.

FGF receptor-2-IIIb is a splice variant of FGFR2 that is predominantly expressed by cells of epithelial origin and is involved in proliferation of these cells, whereas other FGFR2 variant transcripts are detected in mesenchymal cells (Miki et al, 1992).

In consequence, the variant IL4I1_2 transcript is indicative of a so far undetected mechanism of gene regulation.