Since p14 interacts strongly with splicing factor SF3b155, a much larger protein, we designed a p14 variant unable to interact with it.
Phylogenetic inference of chemokine receptors suggests that viral mutational pathway may generate a large variety of R5 variants able to interact with chemokine receptors different from CXCR4.
Similarly, the CXCR4 risk variant was found to interact with NGN3 and CDKN2A/2B SNPs.
An inactive form of ERK2, the H230R variant, which fails to interact with MEK1, but retains the ability to interact with MEK2 in a weakened fashion [39] did not produce the effect of wild-type ERK2 (Fig. 1A).
GST variants are hypothesized to interact with PAH exposures, although previous research has been inconclusive on a possible interaction between GSTs and PAH with respect to breast cancer [ 20, 21].
Common genetic variants are likely to interact with these environmental lifestyle risk factors to modify risk.
Rather than binding to the C-terminal SUN domain of the SUN proteins, these short KASH variants are likely to interact with sequences closer to the N-terminus, as shown with nesprin-2, which appears to have an overlapping binding site with emerin in SUN1 (Refs 31, 39).
In line with the idea of a Fc γRII-dependent mode of CD40 activation, it turned out furthermore that 1C10-derived Fab2 preparations and a deglycosylated form of 1C10, thus 1C10 variants that fail to interact with Fc γ receptors, elicit no adjuvant activity in this model, too.
The PLCE1 variant was further found to interact specifically with tobacco smoke exposure 36.
In HCMV-infected fibroblasts, alternative splicing of the tapasin transcript resulted in an induced level of a tapasin variant lacking exon 3. The tapasin variant had lost the ability to interact directly with MHC I and ERp57, but stabilized TAP expression.
