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Limited to the key functional domains as annotated on Figure 1 (which is derived from Williams et al. [ 4]), and excluding the second DNA binding domain of MRE11A, we observed 23 rMS and one final exon truncating variant that we evaluate as an in-frame deletion (RAD50 c.3852del4).
In the speech previous to the Tyler variant that we shall examine presently, Lady Thatcher began by assailing what she termed the "lamestream media" for having revealed that her confidential speaking contract included demands for bendable drinking straws to be provided at the podium.
RT-PCR analysis of AmNrxI-A identified a spliced variant that we have called AmNrxI-A2 (Figure 4, Figure S5).
It is generated by replacing mECFP with mTurquoise, a novel, very bright and single-exponentially decaying CFP variant that we recently identified [9].
This finding is in line with the fact that the DiCre variant that we have used to establish the DiCre mouse line corresponds to one that displayed a background activity among the lowest in our previous in vitro studies [24], and that it had no discernable background activity in ES cells (present study).
The variant that we have used in this study is in close linkage disequilibrium (LD) with variation within a transcription factor binding site located 5' of CRP that is associated with circulating concentrations of CRP and thought to be functional.[43] [45] It is unlikely that this functional variant, or one in close LD with it, will have pleiotropic effects.
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"It's not just rare variants that we should be thinking about with multiple cancers, but common variants, possibly many of them," says Lindsay Morton, a scientist in NCI's division of cancer epidemiology and genetics.
We will focus on the development of the renal veins and their primitive origin, the subcardinal veins and their anastomoses that explain the multiplicity of variants that we can find.
The two variants that we assessed are not necessarily the functional culprits.
The variants that we observe association to may directly dictate splicing or some other regulatory mechanism but more likely are in LD with the causative variant(s).
We evaluated the 10 SNP model of common LPA variants that we had discovered in JHS in 2200 African Americans from ARIC.
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