Sentence examples for variant since the from inspiring English sources

These observations argue against a defect in classical autophagy mediated by the ATG16L1*300A variant, since the key features of ATG16L1 (binding of ATG5 and other ATG16L1 moieties) needed to form the ATG16L1/ATG5/ATG12 complex are not affected by the ATG16L1*300A variant.

After sequencing both bands we observed a 33 bp deletion before the coding start site in the shorter band which is suggestive for a splice variant since the exon-exon boundary is involved.

This very high DST may underestimate the potential functional impact of a variant, since the majority of variants showing a very high DS have never been observed in mtDNA genomes from both healthy and diseased individuals.

According to serologic testing results, 15 of the 16 SPF herds examined were free from Y. enterocolitica O 3/biovar 4. The first basic nucleus herd at the top of this breeding pyramid has remained free from this pathogenic variant since the herd's establishment in 1996.

In two of the AD loci, we had the opportunity to evaluate the possibility that DNA methylation mediates the effect of the associated variant since both the CR1 index SNP and the APOE e4 haplotype as well as some of the CpGs in each locus are associated with NP burden and AD, which is a prerequisite to formally test mediation.

An early focus of type 2 diabetes pharmacogenetic studies has been the common functional PPARGP12A variant, since this nuclear receptor is the known drug target of the thiazolidinediones (TZDs).

We eliminated all variants detected having less than 5x coverage, allowing at least 2 high-quality reads carrying the variant, since these parameters were already ascertained to produce reliable calls [6].

Bloch-type walls may exist in two variants since the ferroelectric polarization between c-domains of opposite sign can rotate either clockwise or counterclockwise across the wall.

These numbers are based on the pdf-GAL4-driven expression of a nucleus-targeted dsRed-variant, since the cell number was difficult to assess with immunolabelings or membrane-targeted GFP.

The HapMap database is a subset of the dbSNP database and is less likely to include pathogenic variants, since the HapMap data were generated from randomly selected individuals.

Transmitted variants with variable penetrance are commonly termed 'unclassified variants' since the genetic background is critical for their phenotypic expression.